Mechanisms of Inflammation in Neutrophil-Mediated Skin Diseases

Mechanisms of immune-mediated skin diseases: an overview.

The skin is a frequent site of pathological immune responses that can take place in the dermal and/or the epidermal compartments.These immunopathological reactions often occur towards innocuous antigens and may be the result of T cell-dependent and/or autoantibody dependent mechanisms. Defective immune regulation is increasingly recognized as very relevant in many skin and systemic immune-media...

Mechanisms of neutrophil-mediated injury.

The interaction of neutrophils with endothelial cells results in damage or killing of the latter. This outcome requires alteration of the endothelial cells such thatadhesive interactions betweenncutrophils and endothelia! cells are enhanced. In addition, neutrophil stimulation must also occur. To date, the most important adhesion promoting molecules appear to involve either P-selectiii or E-sel...

Molecular Mechanisms of Skin Diseases

Skin diseases in athletes

Sports and the development of nations are very much intertwined. Sports dermatology is a growing discipline. Athletes’ skin diseases are a distinct group of diseases, and that repetitive physical activity combined with environmental stressors puts the athlete at the highest level of risk.The purpose of this study is to equip physicians with basic knowledge of skin diseases in athletes. Lack of ...

Autoinflammatory diseases and the inflammasome: mechanisms of IL-1β activation leading to neutrophil-rich skin disorders

Autoinflammatory diseases were initially assigned to the hereditary recurrent fevers that were characterized by unprovoked episodes of inflammation without antigen-specific T cells or high titers of auto-antibodies, in contrast to the autoimmune diseases in which acquired immunity played an essential role. Except for Blau syndrome and early-onset sarcoidosis that are associated with granuloma d...